DKMORS - Razvoj tkivno inženirskih kostnih nadomestkov : končno poročilo ob zaključku projekta tehnološki program "Tehnologija za varnost in mir 2006-2012" (TP MIR)

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Title	Razvoj tkivno inženirskih kostnih nadomestkov : končno poročilo ob zaključku projekta tehnološki program "Tehnologija za varnost in mir 2006-2012" (TP MIR)
Authors:	Kregar-Velikonja, Nevenka (Project leader)	Language:	Slovenian	Work type:	Applicative research	Organization:	MORS - MORS publications	Keywords:	kostno tkivo, poškodbe, tkivno-inženirstvo, matične celice, kostne celice, biološki kostni nadomestki	UDC:	611.71:612.014	COBISS_ID:	3686094	Statistika:	6969 ogledov; 235 prenosov	Categories:	Document is not linked to any category.
Files:	Razvoj_tkivni_inzinirskih_kostnih.pdf (835,42 KB)
Abstract:	Kostne poškodbe nastanejo kot posledica neposrednega in posrednega delovanja sile, prav tako pa so lahko posledica dolgotrajnih preobremenitev. V primerih kot so zlomi z več kostnimi odlomki, primanjkljaj kosti, odprti zlomi ali ob slabi prekrvavitvi tkiv, je sposobnost kostnega tkiva po obnavljanju največkrat precej okrnjena. Zato se kost zarašča počasi ali pa se celo ne zaraste. Vojne poškodbe okončin in maksilofacialnih kosti predstavljajo indikacije, pri katerih bi ustrezna kirurška metoda, ki bi omogočila učinkovito obnovo (regeneracijo) tkiva, omogočila poškodovancem hitrejše zdravljenje in boljšo kvaliteto življenja po okrevanju.
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Language:	English	Title:	TP MIR 31	Abstract:	The healing potential of bone is mostly sufficient to restore the majority (simple) fractures, which are generally treated by standard conservative or surgical therapy. However, in some cases reparative osteogenesis does not result in structural and functional recovery of the bone. Extended bone defects following trauma or cancer resection or non-unions of fractures may require more sophisticated treatment. In these cases bone grafting procedures, segmental bone transport, distraction ontogenesis or biomaterials are applied for reconstruction. The repair of bone defects in reconstructive surgery is subject to significant limitations, including donor site morbidity, limited supply of autograft, risk of infection and immune rejection of allograft, and poor osteogenic effect of synthetic bone substitutes. In addition, bridging of a large bone defect by callus distraction requires a long time and usually an external fixator, both very inconvenient for the patients. Regardless of the technique used the percentage of failure is considerable. Therefore, bone repair is the subject of intensive investigation in reconstructive surgery.

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Language:

English

Title:

TP MIR 31

Abstract:

The healing potential of bone is mostly sufficient to restore the majority (simple) fractures, which are generally treated by standard conservative or surgical therapy. However, in some cases reparative osteogenesis does not result in structural and functional recovery of the bone. Extended bone defects following trauma or cancer resection or non-unions of fractures may require more sophisticated treatment. In these cases bone grafting procedures, segmental bone transport, distraction ontogenesis or biomaterials are applied for reconstruction. The repair of bone defects in reconstructive surgery is subject to significant limitations, including donor site morbidity, limited supply of autograft, risk of infection and immune rejection of allograft, and poor osteogenic effect of synthetic bone substitutes. In addition, bridging of a large bone defect by callus distraction requires a long time and usually an external fixator, both very inconvenient for the patients. Regardless of the technique used the percentage of failure is considerable. Therefore, bone repair is the subject of intensive investigation in reconstructive surgery.